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Duckweeds for the Production of Therapeutic Proteins

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Exploring Plant Cells for the Production of Compounds of Interest

Abstract

The production of various biopharmaceuticals in transgenic plants (biofarming) is becoming an increasingly popular trend in modern biotechnology. To date, the expression of recombinant proteins in transgenic plants is becoming a powerful alternative to classical expression methods. This is due to the fact that the use of plant expression systems can provide a significant reduction in the cost of recombinant protein production. The main efforts in the field of genetic engineering of Lemnaceae were aimed at obtaining plants-producers for the production of recombinant proteins for various functional purposes, primarily medical. Plants expressing monoclonal antibodies, viral and bacterial antigens, and various therapeutic and industrial proteins have already been obtained. Their biological activity has been confirmed, and researches in the field of the extraction and purification of target proteins have begun. Moreover, some efforts have already been directed at the development of the methods for humanizing the glycosylation of recombinant antibodies in transgenic plants-producers. Given the current progress and pace of development of research in various areas of Lemnaceae biology, we have no doubt that in the near future, we can expect the emergence of efficient and competitive duckweed-based expression systems for the production of recombinant proteins for various purposes.

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Acknowledgments

This study was supported by the Russian Science Foundation Grant no. 19-74-00010.

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Authors and Affiliations

  1. Laboratory of Plant Bioengineering, Nikita Botanical Gardens – National Scientific Centre, Russian Academy of Sciences, Yalta, Russia

    Pavel Khvatkov, Tatyana Mitiouchkina & Sergey Dolgov

  2. Laboratory of Plant Gene Engineering, All-Russia Research Institute of Agricultural Biotechnology, Russian Academy of Sciences, Moscow, Russia

    Pavel Khvatkov, Alexsey Firsov, Tatyana Mitiouchkina, Mariya Chernobrovkina & Sergey Dolgov

  3. Laboratory of expression systems and modification of the plant genome “BIOTRON”, Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Puschino, Russia

    Alexsey Firsov, Tatyana Mitiouchkina & Sergey Dolgov

Authors
  1. Pavel Khvatkov
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  2. Alexsey Firsov
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  3. Tatyana Mitiouchkina
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  4. Mariya Chernobrovkina
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  5. Sergey Dolgov
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Editors and Affiliations

  1. Universidade Federal do Maranhão, São Luís, Maranhão, Brazil

    Sonia Malik

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Khvatkov, P., Firsov, A., Mitiouchkina, T., Chernobrovkina, M., Dolgov, S. (2021). Duckweeds for the Production of Therapeutic Proteins. In: Malik, S. (eds) Exploring Plant Cells for the Production of Compounds of Interest. Springer, Cham. https://doi.org/10.1007/978-3-030-58271-5_5

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