Piera Smeriglio
Senior Postdoctoral Researcher (Marie-Curie fellow)
Presentation
I am a Senior Postdoctoral Researcher in the Biferi’s group since January 2019. I have completed my PhD from “La Sapienza” University of Rome, Italy where I focused my research on the use of pharmacological approach to epigenetic rewiring committed muscle cells into progenitor fate with enhanced regenerative function. I have furthered my study in the epigenetics field at Stanford University, California as postdoctoral fellow in 2012. Using cartilage development and osteoarthritis (OA) disease model, I have uncovered a novel paradigm of epigenetic regulators critical to the regulation of musculoskeletal functions.
My current research in the Biferi’s group focuses on the understanding of the role of epigenetic regulators in motor neuron functions and diseases including the Spinal Muscular Atrophy (SMA), a devastating neuromuscular disorder. My project is supported by an Eropean award from the Marie Skłodowska-Curie Actions as a recognition for the originality of the project and the complementarity to the host laboratory.
Main publications
- Smeriglio, P, Grandi, FC, Davala, S, Masarapu, V, Indelli, PF, Goodman, SB et al.. Inhibition of TET1 prevents the development of osteoarthritis and reveals the 5hmC landscape that orchestrates pathogenesis. Sci Transl Med. 2020;12 (539):. doi: 10.1126/scitranslmed.aax2332. PubMed PMID:32295898 .
- Smeriglio, P, Lee, J, Bhutani, N. Soluble Collagen VI treatment enhances mesenchymal stem cells expansion for engineering cartilage. Bioeng Transl Med. 2017;2 (3):278-284. doi: 10.1002/btm2.10078. PubMed PMID:29313037 PubMed Central PMC5689496.
- Taylor, SE, Li, YH, Smeriglio, P, Rath, M, Wong, WH, Bhutani, N et al.. Stable 5-Hydroxymethylcytosine (5hmC) Acquisition Marks Gene Activation During Chondrogenic Differentiation. J Bone Miner Res. 2016;31 (3):524-34. doi: 10.1002/jbmr.2711. PubMed PMID:26363184 PubMed Central PMC4860191.